Cognitive function in Familial Adenomatous Polyposis: anyone out there listening?

Results 44 subjects from 42 families (22 men), mean age of 42 years were included. KBIT-2 Composite IQ score was 98.4 ± 12.4, (95% CI (confidence interval) 94.5-102.3) which is within the average range of 90-109. 27 % of patients scored below average (less than 90) and 15% scored above average (greater than 109), not a significant imbalance (sign test p=0.33). Nonverbal IQ scores show no difference from average, mean=100.5; 24% scored below and 27% scored above average. Verbal scores were 95.5 ± 12.0 (95% CI 91.7 -99.2) significantly lower than average (one-sample T-test p=0.020). There is an imbalance among patients with 27% below and 7% above the average range and a tendency toward lower than average scores (sign test P=0.06). The mean number of points by which Nonverbal IQ exceeded Verbal IQ was 5.0 ± 12.5 (95% CI 1.1 -9.0), (one-sample T-test p=0.013). The non-verbal score exceeded the verbal score for 27 patients (65.9%), while the verbal score was larger for only 10 patients (24.4%) (Sign test p=0.008).